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10.1158/1078-0432.CCR-11-3281 84 RennardS

The expression of occludin, a protein involved in maintaining tight junction barrier properties, glial cell-derived neurotrophic factor (GDNF), associated with spermatogonial self-renewal, and transforming growth factor-beta (TGF-), implicated in injury repair processes, were analyzed in Sertoli cells
The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes

It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses
