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Immunocompromised individuals or those on systemic retinoids may experience additive dryness and should initiate treatment with the Sensitive strength only under close monitoring

Oleandrin, a cardiac glycoside and the active ingredient in PBI-05204, targets glioblastoma stem cells by downregulating glucose-regulated protein 78 (GRP78) and inducing necroptotic cell death [93]

The GP reaction is: 2GSH + H 2 O 2 GS-SG + 2H 2 O where GSH represents reduced monomeric glutathione, and GS-SG represents glutathione disulfide

If irritation persists beyond the first week, consider reducing frequency or switching to a lower concentration