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This tripeptide is ubiquitous in nature and is produced by every organism from bacteria to plants to animals that derives energy from oxidative phosphorylation and respiration

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Synthesis of disulfide linker functionalized (+)-MK-801 and inactive MK-801 2-Mercaptoethanol (Sigma-Aldrich) was treated with 2,2-dipyridyl disulfide (3 equivalents) (Sigma-Aldrich) in dry methanol for 2 h