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The C-domain is composed of an alpha/beta super-secondary structure, which is common of the Rossmann fold

Activated fibroblasts secrete a significant amount of collagen fibers at the periphery of the granuloma, forming a dense capsule that ultimately creates the three-layer pathological structure of classic gout stones: the inner MSU crystal core, the middle chronic inflammatory granuloma zone, and the outer fibrous capsule

These groups would need to ensure they are getting adequate calcium, vitamin D and magnesium through their diet as these are critical for bone health

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