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Analysis of clinical data clearly demonstrates that mitochondrial dysfunction accompanies disease progression in a substantial proportion of patients

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The clinical trials on combining EpCAM targeting with other immunotherapies (such as checkpoint blockade) are ongoing

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Gut mucosal barrier Treatments that restore the gut barrier and prevent bacterial translocation have the potential to remove underlying causes of infection, inflammation, and immune activation in critical illness [308]

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How cells may normally prioritize limited intracellular GSH pools for use in nucleotide synthesis versus lipid hydroperoxide reduction is an important direction for future investigation

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