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Analysis of clinical data clearly demonstrates that mitochondrial dysfunction accompanies disease progression in a substantial proportion of patients

The clinical trials on combining EpCAM targeting with other immunotherapies (such as checkpoint blockade) are ongoing
Gut mucosal barrier Treatments that restore the gut barrier and prevent bacterial translocation have the potential to remove underlying causes of infection, inflammation, and immune activation in critical illness [308]

How cells may normally prioritize limited intracellular GSH pools for use in nucleotide synthesis versus lipid hydroperoxide reduction is an important direction for future investigation
