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Concurrently, a weakening of prefrontal inhibitory control over these limbic structures, mediated by dendritic atrophy and reduced connectivity, leads to a loss of topdown regulation, resulting in negative affective states, cognitive deficits, and the persistence of pain memory [85, 86, 87]

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A randomized controlled study demonstrated that acupuncture combined with methylcobalamin is more effective in treating BIPN than methylcobalamin alone (Moore et al., 2020)

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Each problem requires a different approach

l carnitine arginine doctor's best Doctor's Best Sustained Plus Immediate Release L- Arginine, Non-GMO, Vegan, Gluten NHS Arnitine, L-Carnitine + L-Arginine

demonstrated that the GPX4 inhibitor RSL3 selectively promotes ferroptosis in DCs (72)

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