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In the recently completed parallel-group phase 1 clinical trial, the AFF008 study series assessed the tolerability and safety of repeated subcutaneous administration of a synthetic -syn mimicking epitope called AFFITOPE PD01A in a group of 24 patients randomized to receive either AFFITOPE PD01A low dose or high dose (NCT01568099)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [203].Wang X-M, Gu P, Saligan L, Iadarola M, Wong SSC, Ti LK, Cheung CW, Dysregulation of EAAT2 and VGLUT2 Spinal Glutamate Transports via Histone Deacetylase 2 (HDAC2) Contributes to Paclitaxel-induced Painful Neuropathy, Mol

Nicotinamide adenine dinucleotide phosphate (NADPH), functioning as a dehydrogenase cofactor, is an essential reducing agent for clearing lipid hydroperoxides (STOCKWELL et al., 2017)