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Study Design: The complexity of the study and the number of endpoints will influence the choice of animal model
Consistent exposure maintains the signaling that triggers collagen synthesis and other beneficial effects
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Concomitant treatment Recording of the taking of protein pump inhibitors, H2 receptor antagonists, antacids, potassium, metformin, colchicine, neomycin, p-aminosalicylic acid, parenteral chloramphenicol, Fe, vitamin C and other vitamin supplements
