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Research shows that low vitamin B12 status is associated with significantly increased decline in cognitive performance over time

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Together with serum cobalamin concentration, it can also be useful to monitor serum MMA levels, since MMA reflects the actual bioavailability of the vitamin

Pinotti M, Bertolucci C, Frigato E, Branchini A, Cavallari N, Baba K, Contreras-Alcantara S, Ehlen JC, Bernardi F, Paul KN, Tosini G