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85,87 In a study of Dutch community-dwelling geriatric outpatients, after adjustment for gender and age, statistically significant negative associations were found between use of metformin and vitamin D status, with those non-supplement users of vitamin D having levels of the vitamin 14.4% lower compared to controls
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allometric exponent on CL = 0.8 (BW^0.8)
It is not a toxicity concern but an efficacy consideration
