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In the corpus callosum of cuprizone-fed mice, overall RIPK1 levels and RIPK1 + oligodendrocytes increase until week 5 of treatment

The present hallmarks of the modern cuprizone model To standardize the cuprizone model, Hiremath and colleagues introduced a protocol for lower-dose cuprizone administration (0.2% w/w) in C57BL/6 mice in 1998 [42, 43] that is still widely used today

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