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In support of this conclusion a recent meta-analysis of 146 articles reporting PZQ efficacy as CR and ERR, has concluded that PZQ has retained its efficacy despite its extensive use for over four decades ( 6 Factors preventing the establishment of PZQ resistance in the field An array of factors could prevent the emergence and establishment of PZQ resistance in the field, and are further considered in this section ( Figure 3 )

Though this feature is not adaptive from an energy point of view, by making alcohol in such high concentrations so that they would be toxic to other organisms, yeast cells could effectively eliminate their competition

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