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Meanwhile, we detected the HIF-1, a key protein in the mechanism of APAP-induced liver injury 35 and found that 5-HT could decrease the expression of HIF-1 by which 5-HT contributed to relieve of APAP-induced hepatotoxicity (Figure 8D and 8E)

Additionally, IGFs can bind both the IGF-1R and the IR due to structural homology between the receptors [156,157,158]