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[PubMed] [Google Scholar] Fiala S., Mohindru A., Kettering W
49 As a core circadian regulator, melatonin stabilizes clock genes (e.g., CLOCK protein), reduces cortisol-mediated immunosuppression, and coordinates rhythmic immune cell activities (e.g., diurnal fluctuations in macrophage phagocytosis), systemically delaying immunosenescence
Sign 2: Insomnia and Sleep Disturbances Another common sign of benzodiazepine withdrawal is insomnia and sleep disturbances
10.1128/IAI.01282-10 47 MoranC.GrussemeyerC
