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von Laar J, Stahl W, Bolsen K, Goerz G, Sies H

[0366] In another embodiment, a recombinant DNA vector is used to transfect a cell line that produces an antibody having a desired effector function, (e.g., a constant region of a human immunoglobulin) in which case, the replacement gene contained in the recombinant vector may encode all or a portion of a region of an ALPPL2/ALPP specific antibody and the target sequence contained in the recombinant vector allows for homologous recombination and targeted gene modification within the antibody producing cell

With 2.5mL or 5mL of water, the 1.7mg and 2.4mg doses require drawing volumes that exceed a standard 100-unit (1mL) syringe

Boroughs LK, DeBerardinis RJ