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Aside from its role in phagocytosis of foreign antigens, another physiological function of macrophages is to maintain the iron balance in human tissues

Bacteria and yeast consume most of it, converting it into acids and CO2

Intramuscular B12 injections represent the standard treatment for deficiency due to malabsorption (such as pernicious anaemia) or when neurological symptoms are present

The neurovascular unit uncoupling initiates glial activation, neuronal apoptosis, blood-retinal barrier leakage, and ischemia, shifting the understanding of DR from a solely vascular disorder to a neurovascular one where early NVU impairment predicts functional deficits like reduced contrast sensitivity and progression to vision-threatening complications (34)