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Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: a phase II pilot study

Biomed Pharmacother 2003

Updated on August 17, 2023 Article Summary Although thyroid problems can have a devastating impact on physical and emotional health, individuals have historically had few options for proactively supporting thyroid health before diagnosable conditions arise Given the role glutathione plays in thyroid hormone regulation, evidence suggests that glutathione supplementation could help maintain thyroid health* Using a glutathione supplement to support thyroid health could be particularly important for individuals with a family history of thyroid problems or who have been exposed to unusually high levels of oxidative stress* For healthy individuals, their thyroid gland receives only minimal attention in general health habits, but for individuals with autoimmune diseases or genetic abnormalities, maintaining the peak performance of the thyroid can be an uphill battle

Mechanistically, we show that this effect occurs independently of canonical melatonin receptor signaling in ILC2s and instead requires activation of the NRF2-glutathione axis