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A ligand that is endocytosed and/or transcytosed into and/or through the target cell is herein defined as a ligand that is endocytosed or transcytosed into or through a BCEC or MDCK target cell at a rate that is at least 5, 10, 20 or 50% enhanced as compared to control conditions selected from a) cells lacking expression of GSH transporters

However, antibiotic resistance now represents a critical factor in the failure of ulcer treatment (Homan 2015

[20] It is important to note that doses higher than 600 mg/day intravenously have not been shown to confer additional clinical benefit, but they may increase side effects

Not only does this result in reduced availability of NO for vasodilation, but ROS and RNS can also induce the proliferation of smooth muscle cells and stimulate the expression of cell adhesion molecules, mostly ICAM-1 and VCAM-1, that control the inflammation on the vascular level by leukocyte migration and adhesion [52]