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Description
Tesamorelin FDA-approved for HIV-associated lipodystrophy, its used off-label to reduce abdominal fat and improve metabolic health
By inhibiting NNMT, 5-Amino-1MQ aims to elevate intracellular levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme absolutely fundamental for cellular energy metabolism, DNA repair, and overall cellular function
NNMT inhibition still occurs, NAD+ still rises, and sirtuin activation still happens
More critically, this masking, although neither complete nor permanent, can permit neurologic dysfunction to develop and sometimes become irreversible
