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Additionally, microneedle structures can provide mechanical stimulation and allow for the loading of drugs to promote wound healing [146]

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13.5 Balancing safety with clinical benefit Among the primary safety concerns associated with probiotic administration are opportunistic infections, as immunocompromised individuals face a significantly increased risk of systemic infections originating from probiotic strains

The sacral region (vertebrae S1-S5) includes a large bone at the bottom of the spine
