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Pinto-Sanchez MI, Hall GB, Ghajar K, et al
The GSH depletion was the earliest event in BSO plus HCH-induced signaling and the apoptotic effect of this combination was correlated with the enhanced depletion of GSH as glutathione precursor GME abrogated activation of JNK, ERK and the apoptosis
It was reported that Se deficiency in the human body was associated with an increased risk of AD ( HD HD is an autosomal dominant neurodegenerative disease caused by the CAG repeat length mutation in the huntington gene (Ross and Tabrizi, 2011)
Mitochondrial oxidative stress in Alzheimer's disease (AD) drives A accumulation and tau hyperphosphorylation, exacerbating neuronal damage (70)
