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These reactions happen when the body reacts to the supplement

As previously proposed based on kinetic analysis of functional data 20,31,32 , our model posits the presence of one pre-active state (P) and two desensitized state configurations, which we correlate with partially (D) and fully ruptured (D) states, respectively

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Upon co-expression with GluK2, all GluK5 variants produced desensitizing glutamate responses and resulted in similar surface expression levels compared to GluK5(wt) (Fig