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Specifically, curcumin can stimulate the transcription of microRNA-125a (miRNA-125a), a small RNA species capable of regulating multiple targets post-transcriptionally, including translational suppression of ERR ( Curcumin may offset ATZs potential breast cancer-progressive effects via the EGF signaling cascade The mitogen epidermal growth factor (EGF) and its associated signaling cascade are essential in both normal development and the progression of many malignancies ( Figure 4A )

Another major route of cholesterol delivery to the liver is mediated through LDL and the LDL receptor (LDLR) (Figure 6) (701)

Supplementary Data 1 (download XLSX The proteomics dataset and COG classification results shown in Fig