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doi: 10.3390/biomedicines9101300

To protect the cell and mitochondrial constituents, mitochondria deploy several ROS antioxidants that are adept at neutralizing ROS before oxidative damage can occur (Alexeyev, Drosophila , for example, targeting catalase to the mitochondria nor overexpression of superoxide dismutase, catalase, and thioredoxin reductase extended lifespan (Mockett et al., 2003, 2010

Combined treatment with IC261 and APR-017 resulted in a remarkable reduction in cell viability and a significant increase in ROS level when compared to the control or single treatment groups (Fig

Data availability Structure factors and atomic coordinates have been deposited in the Protein Data Bank (PDB) under accessions: MavL-ADPR (PDB:8IPW), MavL40-404(D315A)-ADPR-Ub (PDB:8IPJ), LnaB-actin (PDB:8J9B)