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While NO inhibits the activity of the cytosolic APX in tobacco Bright Yellow-2 suspension cells through S -nitrosation (de Pinto et al

Journal of animal science 100(4):skac086

This conclusion was further supported by HSP60 and DRP1 immunofluorescence co-staining, which demonstrated that KU-57788 treatment rapidly induced the translocation of DRP1 from the cytoplasm to mitochondria in ATC cell lines 8505C and Hth-7, coinciding with mitochondrial fission (Fig

A program without a target cannot be optimized through medicinal chemistry, cannot generate target-engagement biomarkers and cannot be de-risked for off-target liabilities
