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Throughout the 1990s and 2000s, the Orange Book expanded its listings and refined its therapeutic equivalence codes, providing clearer guidance on drug substitutability.[1] The Orange Book Goes Online The transition to an online format in 2005 marked a major advancement, making the Orange Book more accessible and allowing for real-time updates.[2] Today, it remains an indispensable tool for healthcare providers, pharmacists, drug manufacturers, and legal professionals, playing a pivotal role in ensuring the availability of safe and effective generic drugs, promoting competition in the pharmaceutical market, and supporting informed decision-making in healthcare

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