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KD has also been shown to cause changes in amino acid metabolism, in particular, a reduction in levels of -aminoadipic acid, a key biomarker of cancer (222)
On the contrary, despite the existence of limited contradicting studies regarding PSEN1 gene, in vitro and in vivo studies have associated B-vitamin deficiency with enhanced PSEN1 expression due to hypomethylation of its promoter [179,180]

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