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doi:10.1007/s00394-014-0718-8

Here, I review current significant evidence of the contribution of pineal dysfunction in AD to the progress of AD neuropathology

Physiological functions of mitochondrial fusion
Critically, the integrity of this initial pulmonary barrier can be compromised by inhaled toxic substances (e.g., PM., O, cigarette smoke), which downregulate tight junction proteins and increase epithelial permeability