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In addition, the aggregation of -synuclein into Lewy bodies is a pathological hallmark, and its toxic gain-of-function is believed to exacerbate neurodegeneration through mechanisms such as proteotoxicity and synaptic dysfunction [17, 18]
doi:10.1002/pro.3 41
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10.1016/j.bbr.2011.12.027 162 HamadM