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Treatment with 5-Amino-1MQ improved grip strength to a greater extent than exercise training alone in aged mice

Nat Rev Gastroenterol Hepatol 20 , 238253 (2023)

Interestingly, a previous study demonstrated that limiting cholesterol flux could aggravate the IFN and ISG response in a STING-dependent manner in macrophages (115), and its precursor concentration, 7-dehydrocholesterol (7-DHC), could also significantly increase I-IFN production via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B 3 (AKT3)-interferon regulatory factor 3 (IRF3) pathway (116)