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Targeting ferroptosis against ischemia/reperfusion cardiac injury
doi: 10.1111/aji.13786
doi: 10.17116/jnevro202012003254
Within the cytosol of cells, glutathione is kept primarily in the reduced GSH form, largely by reduction of GSSG by the enzyme glutathione reductase, at the expense of NADPH: The mechanism of this reaction is complex, as the enzyme contains a pair of cysteine residues that reversibly form a disulfide bond, plus one FAD molecule (3)
