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A dilute concentration of epinephrine (1:200,000) usually reduces the rate of absorption and peak plasma concentration of bupivacaine, permitting the use of moderately larger total doses and sometimes prolonging the duration of action

Targeted Local Applications While subcutaneous injection provides systemic distribution, injecting closer to specific target areas may enhance local effects

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As with any peptide therapy, proper dosage, cycle length, and medical supervision are crucial for safety