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Figure 16.27 Distribution Curve Showing the Fraction of Acetic Acid Molecules and Acetate Ions as a Function of pH in a Solution of Acetic Acid The pH range over which the acetic acid/sodium acetate system is an effective buffer (the darker shaded region) corresponds to the region in which appreciable concentrations of both species are present (pH 3.765.76, corresponding to pH = p K a 1)

Thus, the interactions of FcRn with IgG and albumin are distinct, and the two ligands bind the receptor non-competitively and simultaneously to effectively form a ternary IgG:FcRn:albumin complex [26, 72]