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Although first defined in 2012, as early as 2003, when high-throughput screening revealed compounds with the ability to kill engineered tumorigenic cells, this nonapoptotic cell death, now known as ferroptosis, was initially characterized and shown to be induced by Erastin[1, 8, 9] (Figure 1)

However, we believe that the notion of levels of evidence used to assess the efficacy of drugs cannot be applied in the same way to assess the safety of drugs

26 Early clinical studies showed that hepatomegaly caused by chronic alcohol consumption resulted in part from accumulation of protein in the liver