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Lifelong choline supplementation in another Alzheimers disease mouse model (APP/PS1 transgenic mice), significantly diminished amyloid- plaque load and decreased activated microglia, thereby mitigating the detrimental effects of brain inflammation associated with Alzheimers disease (44)

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l-Carnitine dissimilation in the gastrointestinal tract of the rat

The ubiquitous vitamin B 12 -dependent methionine synthase (MS) enzyme also catalyzes the re-methylation of homocysteine, using the folate derivative, 5-methyltetrahydrofolate, as a methyl donor (see Nutrient interactions)
