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For example, I/R injury induces massive hepatocyte necrosis: the cell membrane of necrotic cells ruptures completely, mitochondrial structure disintegrates, and mtDNA is directly released into the extracellular fluid
It was thus reasonable to assume that the SLC, more precisely 5, which corresponds to the C L domain, could also induce the folding of the C H 1 domain
Moreover, posttranslational modifications (PTMs) are a major determinant behind the diversity of tau
