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PubMed Central PMCID: PMCPMC3869626
66,67,68,69 Beyond NF1 deletion, only one of these studies observed any CNVs in cNF, and this was a gain of CCND1
Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate
In addition, LKB1 inactivation, in conjunction with KRAS G12D mutation, promotes serine biosynthesis, contributing to DNA methylation and the enrichment at retrotransposon elements associated with their transcriptional silencing [102]
