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Description

Several urinary metabolites derived from cytochrome P450 2E1 mediated bioactivation of furan to the highly reactive intermediate cis -2-butene-1,4-dial (BDA) and subsequent reaction of BDA with cellular nucleophiles such as free or protein-bound lysine and cysteine residues and glutathione (GSH) have been suggested as potential biomarkers of furan exposure (Kellert et al