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10.1016/j.biopsych.2012.08.002 Biol

Indeed, the reduced expression of mitophagy proteins, such as SIRT1, SIRT3, PGC1, and Nrf2, was observed in AD, and this effect was associated with defects in mitochondrial biogenesis and response to OS (229, 231)

On the other hand, increased levels of OS impair key players of the glucose metabolic pathway, which further feed glucose hypometabolism (6, 133, 377)
