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In another study, ECs exposed to shear stress showed a downregulation of Rho activity due to integrin binding to the ECM, which allowed the ECs to reorganize their cytoskeletal elements and align with the flow (221)
Preclinical research suggests effects related to angiogenesis (VEGF/nitric oxide pathways), anti-inflammatory signaling, and tendon, ligament, muscle, and nerve healing, including cytoprotective effects in ischemia
& Frankena, K
The abdomen and thigh are the most commonly recommended because they offer the best combination of subcutaneous fat for absorption and ease of self-administration
