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In ESCC patients, high NRF2 expression is associated with reduced PFS, OS as well as unfavorable therapeutic outcomes [209]

Curr Opin Pharmacol, 7(4), 355-359

10.1016/j.fct.2013.11.015 36 HuY.SchnablB.StarkelP

Importantly, there are numerous studies showing, through the regulation of the aforementioned transcription factors and more, that 4-HNE causes cell cycle arrest and inhibits the proliferation of malignant cells through the p53 and p21 dependent pathways (for review see ( Another important signalling metabolite that is generated through the cyclooxygenase-mediated peroxidation of PUFAs is malondialdehyde (MDA)
