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Wang, W.-T

Many MCAS patients have impaired pathways for converting glutamate into calming GABA, leading to "glutamate excitotoxicity"which can manifest as severe anxiety, insomnia, heart palpitations, and brain fog
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We showed that GCLC is phosphorylated directly by activation of protein kinase A (PKA), protein kinase C (PKC) or Ca 2+ -calmodulin kinase II (CMK) [128]
