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Across neurons and glia, mitochondria provide bioenergetic support, regulate Ca 2+ dynamics and reactive oxygen species levels, influence neurotransmitter synthesis and turnover, and sustain quality control programmes that preserve cellular integrity
While EGFR family members can compensate IGF-IR inhibition and confer resistance to IGF-IR-targeted agents, IGF-IR can confer resistance to EGFR/ErbB2/ErbB3-targeted therapies as well
