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This was further supported by gene set analysis which indicated IR most potently regulated of metabolic pathways (glucose, pyruvate and cholesterol metabolism), as well as genes in the hypoxia inducible factor and protein turnover pathways, and genes implicated in diabetes (Supplementary Table 2)
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A2AR adenosine signaling suppresses natural killer cell maturation in the tumor MicroenvironmentAdenosine impairs proliferation of terminal NK cells
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