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In people over 60, the prevalence is around 2%.[ref] The lack of vitamin B12, though, can cause symptoms long before developing pernicious anemia

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The physician should provide information to the patient about the signs and symptoms of hepatotoxiciy that should cause alarm (e.g., nausea, fatigue, lethargy, pruritus, jaundice, right upper quadrant tenderness and "flu-like" symptoms)
