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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

Similarly, in GPx1 / mice, deficiency of GPx1 increased ROS (as measured by DCF fluorescence of brain homogenates), lipid peroxidation, and protein carbonylation in brains exposed to the A peptide, whereas forced overexpression of GPx1 in the GPx1 / mice attenuated these detrimental effects [124]

Beyond its role as a protector, it helps recycle other antioxidants like Vitamin C and Vitamin E, making them more effective

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