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Cisplatin is one of the most efficacious, and, although its use produces several side-effects, it is still a drug of choise for treating a number of solid cancer 74,75

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In the current HepG2 cell model, in which prolonged exposure is not feasible, the use of relatively high QI concentrations in a short timeframe allows for the identification of underlying mechanisms and pathways, as has been done previously in similar studies with hepatic toxicants (Tafazoli and OBrien, 2009