what is one reaction that involves glutathione Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Glutathione Metabolism and Its Implications
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Tang XX, Ostedgaard LS, Hoegger MJ, Moninger TO, Karp PH, McMenimen JD, et al
DOI: 10.3945/ajcn.110.003483
O., & Onyema, O
Once the glucuronide conjugation and sulfation pathways are saturated, excess acetaminophen is oxidized via the cytochrome P450 microsomal enzyme, resulting in the formation of NAPQI, a highly toxic metabolite [111]
