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Theoretical mitogenic risk from sustained IGF1R activation exists but has not been established or quantified in any human trial
For example, fucoxanthin was found to induce a G0/G1 phase block in cancer cells while upregulating GADD45, a DNA repair gene regulated by p53, which helps maintain genomic stability and reduce cancer risk (44)
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Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism
