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Researchers posit that this underdevelopment of type II collagen fibers is due to apoptosis

USA 107 , 44484453 (2010)
In addition, the binding of LPS to the Toll-like receptor 4 (TLR4) complex activates NADPH oxidase and promotes mitochondrial ROS generation, while simultaneously inducing iNOS expression (Galley, 2011

Pgc-1alpha-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions
